• One of the Brainspawns says, "Are you insane in the membrane?", a reference to the song "Insane in the Brain" by Cypress Hill.
• The Infosphere looks like the "Death Star" from the Star Wars movie series.
• Nibbler uses his third eye to create a flash which erases Fry's memories of what happened throughout the episode, just like the Neuralizer used in Men In Black.
• Professor Farnsworth does not appear in this episode at all.
• Amy reads a book called "Marsians Are from Mars, Venusians Are from Venus", a reference to the book "Men Are from Mars, Women Are from Venus".

Continuity Edit

• Nibbler's shadow can be seen in the cryogenics lab in Space Pilot 3000
• Nibbler tells Fry he will be stationed on Vergon 6, where they meet in the episode Love's Labours Lost in Space
• Nibbler reminds Fry about previously fighting the Brainspawn in the episode The Day the Earth Stood Stupid