- One of the Brainspawns says, "Are you insane in the membrane?", a reference to the song Insane in the Brain by Cypress Hill.
- The Infosphere looks like the "Death Star" from the Star Wars movie series.
- Nibbler uses his third eye to create a flash which erases Fry's memories of what happened throughout the episode, just like the Neuralizer used in Men In Black.
- Professor Farnsworth does not appear in this episode at all.
- Amy reads a book called "Martians Are from Mars, Venusians Are from Venus", a reference to the book "Men Are from Mars, Women Are from Venus".