- This episode tests Zoidberg's competency as a doctor (it's shown that he's a fine doctor for aliens, just not for humans or robots).
- This episode reveals that Mom's real name is Carol.
- The song that plays when Zoidberg tries to kill the Professor is Mr. Sandman, performed by Chet Atkins.
- Fry refers to the Professor's transformation as being "...some kind of believable Hulk!", referencing The Incredible Hulk superhero franchise.
The Tip of the IcebergEdit
The title of this episode is a reference to the saying: "the tip of the iceberg".
Rube Goldberg machinesEdit
The elaborate killing machine the Planet Express crew made to kill the professor is a reference to Rube Goldberg machines
When Fry got sick he looked like different four different cartoon characters:
- A Simpsons character, in which he said Bart Simpson's catchphrase,"¡Ay, caramba!" (Spanish for "Oh, no!")
- Garfield, in which he said Garfield's catchphrase, "I hate Mondays."
- Kermit the Frog, in which he said, "It's not easy being gangrenous", as opposed to Kermit's catchphrase "It's not easy bein' green".
- A Smurf.
Superman and Little CaesarsEdit
Zoidberg blurts "Great Little Caesar's ghost!", which references Superman's catchphrase "Great Caesar's ghost!", as well as the pizza restaurant chain, Little Caesars.
Bender says to the professor "What' choo talkin' 'bout, Professor?". This is a play on the catchphrase of Arnold Jackson from the television sitcom from the late '70s, called Diff'rent Strokes, which he says to his brother, Willis, "What' choo talkin' 'bout, Willis?"
The Three StoogesEdit
Mom tells her sons to "stooge" out of her office. This is a reference to the Three Stooges.
The Tritonian Yeti's appearance and poisonous nature is similar to Mugatu from the Star Trek episode "A Private Little War".
In the episode "Lost Verizon", when the Warriors run away, one of them says the Zoidberg "whoop"-ing