The episode has many references to the Bible. The Jewish people (Mutants) are oppressed and someone from their oppressor's side, Moses, fights for them (Fry). Fry also says "Let my people go", which is what Moses says to Pharaoh. The water (Tidel wave) parts when Moses holds up his staff (The crystal).
When the mutants are swept away, Leela's father says 'They're with the C.H.U.D.s now.' This is a reference to the 1980's film C.H.U.Ds (Cannablistic Humanoid Underground Dwellers) and to it's sequel Bud the C.H.U.D.
The Land Titanic has several reference to the actually Titanic
The Land Titanic sank in 2912, while the actual Titanis sank in 1912.
On the Land Titanic 2000 soules where lost, and on the actual Tictanic around 1500 souls where lost.
The Land Tictanic hit a mailbox and sank, ans the sctual Titanc hit an iceberg and sank.
The Land Titanic was the largest street-going vessel ever build, and the sctual Titanic where the largest ship ever build.
Mrs. Astor is a character on Futurama with a husband names Mrs. Astor who sank with the Land Titanic. Madeleine Astor was a real living person and a survivor on the real Titanic, and a widow of her millionaire husband, John Astor, who sank with the Titanic.