"My nose, light of my face," said by Fry, is a reference to Lolita.
Spanish Fly is a well known aphrodisiac, made from crushing a beetle of the same name. The title is an obvious allusion.
Name of the shop is "The Beast with Two Bucks". Apparantelly, that is a reference to the horror movie The Beast with a Million Eyes, as stated on The Beast with a Billion Backs, where this reference has been made again.
The alien spaceship's tube that abducts Fry is a reference to the popular screen saver included with windows.
Lrrr's line, "One of these days, Ndnd, bang! Zoom! Straight to the 3rd moon of Omicron Persei 8!" is a parody from The Honeymooners, where Ralph would say a similar line to his wife, Alice.
Farnsworth exclaims, "Fry, what in Sega Genesis happened to you?" Sega Genesis is the American name for the Sega Mega Drive.
At the begining of the episode the alien writing says " Thanks for watching, Futurama slave army!"
As in many earlier episodes, the The Scary Door is shown.