The mutants were mainly scavengers, relying heavily on the things the New New Yorkers flush down the toilet. They were led by Mayor Raoul.
They had a well established village, with a seemingly vibrant economy as evidenced by the existence of stores and restaurants reminiscent of 20th century corporate chains. They had quite a few young people in the village, and the local teacher was Dwayne. Unfortunately the school was destroyed after a motorized sewer race between Leela and Moose went out of control.
The mutants worshiped a large unexploded nuclear missile, however:
|“||Nobody’s that observant, it’s mainly a Christmas and Easter thing.||”|
The following mutants have been identified in this show:
- Andy Goldman - The oldest of the mutants. He lives in the sewers of Old New York and has mutated to have his head conjoined onto a mutant's right shoulder.
- Colonel - A frog-like mutant with six eyes.
- Devo - A band that has existed into the 30th Century as mutants.
- Mutated Mark Mothersbaugh - A mutant version of Mark Mothersbaugh. He has four eyes, octopus tentacles for legs, and his DNA is 40% potato.
- Dwayne - A mutant with two noses and a deformed head.
- Fly Mutant - A mutant with the eyes and tongue of a fly and the body of a human.
- Leg Mutant - A mutant that was just a leg with a face on it.
- Mandy - A teenage mutant with snail-like eyes and a scaly body.
- Moose - A teenage mutant with the nose of a pig and the antlers of a moose.
- Mr. Astor - He mutated into a slimy form with octopus-like tentacles upon falling into the polluted sewer lake following the sinking of the Land Titanic.
- Raoul - The Mayor of the Mutants. He has an arm growing out of his head.
- Turanga Leela - She only had one eye and her parents left her at the orphanage where she grew up believing that she was an alien.
- Turanga Leela's Grandma - The unnamed grandmother of Turanga Leela who has three eyes, four tentacles, one human arm
- Turanga Morris - Turanga Leela's dad who has one eye and a sideways mouth.
- Turanga Munda - Turanga Leela's mom who has one eye and tentacles in place of her arms.
- Vyolet - She had a reptilian appearance.
- Mutant nurse - The Nurse with seven eyes and four horse hooves