Mildred Fry
From Futurama Wiki
Mildred was a waitress that Fry met when he traveled back in time. Fry had sex with her knowing that Mildred was his grandmother after his his illegitimate grandfather Enos Fry was killed in a house Fry drove him to that turned out to be a test site for an atomic bomb. She believes that Fry reminds her deeply of Enos, and immediatly begins flirting with him, even taking off her uniform to reveal her undergarment. Through this action, Fry became his own grandfather.
