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Joe may refer to:
- "Curly" Joe, a Harlem Globetrotter.
- "Fishy" Joseph Gilman, owner of a chain of restaurants.
- Joe, a half camel, half human alien.
- Joe, someone who was cryogenically frozen.
- Joey Mousepad - a member of the Robot Mafia.
- Joe, the member of the Nation of Joe.
- JoJo, a grizzly bear that was served at the Amy at Elzar's Fine Cuisine.
- Orange Joe, a pseudonym used by Fry in "Fun on a Bun".