Before protecting Lucy Liu's head from the rampaging clones, Bender is revealed to have been storing Pavarotti's head.
This episode may be encouraging people not to pirate and not to buy pirated things
When they're about to leave Nappster, George Michael's head says, "Please, pick me up before you go-go". This is a reference to the song "Wake Me Up Before You Go-Go", performed by Wham!, which George Michael was a part of.
The violent Liu-bots are much like Lucy Liu's character in the Kill Bill films by Quentin Tarantino. Kill Bill came out in 2003.
The educational tape is a parody of anti-homosexual educational movies of 1950s.
The introduction scene can be seen as a reference to Twin Peaks as there is a casino named 3-Eyed Jack's Casino (similar to One-Eyed Jacks, a casino and brothel in Twin Peaks) and red curtains in the scene with the slot machine (which are the background for The Black Lodge, a supernatural realm).