|First appearance||The Day the Earth Stood Stupid|
|Voiced by||Maurice LaMarche|
- "The Big Brain am winning again. I am the greetest! Now I am leaving Earth for no raeson!"
- ―Big Brain, reading Fry's writing[source]
The Big Brain is the leader of the Brainspawn. He is a massive brain who lives in the Infosphere.
The Big Brain conducted several attacks on other planets by rendering their population stupid and then destroying the planet. The Big Brain helps Fry travel back to the past to stop himself from being frozen. The Brainspawn's goal is to gather all of the universe's information into the Infosphere. He was most likely destroyed when Fry blew up the Infosphere.