When Bender sees the "puddle" of tiny Benders on the floor of the staff room he says, "What is all this grey goo?" This is a reference to the hypothetical end of the world scenario involving self-replicating robots consuming all the matter on Earth to build more of themselves; the scenario is called "Grey Goo".
The episode features an episode of "The Scary Door", Futurama's ongoing parody of The Twilight Zone.
We learn that Zoidberg is married to an unknown woman who has not yet appeared in the show. This is proven when Farnsworth sheds a book that says Zoidberg's wedding album
It is revealed that knitting is one of Zoidberg's hobbies
The voices of Bender (John DiMaggio) and Giant Unattractive Monster (Patton Oswalt) also voice two rival villains on the show Kim Possible, Dr. Drakken (DiMaggio) and Professor Dementor (Oswalt.)