The city scene in the initial seconds of film on Farnsworth life shows a billboard "Slurm, Medicinal Tonic". This is likely a parody of the popular soft-drink Coca-cola, which had its origins as a medicinal remedy.
The birthplace of Farnsworth is mentioned as "Hell's Laboratory", likened to Hell's Kitchen, Manhattan in New York.
During the escape from the Near Death Star, the Bullet Time camera technique, which was heavily incorporated into the The Matrix movies, is used to pan around Planet Express ship for a climactic conclusion, as well as referencing the ship's unique engines.
The Near Death Star and the crew's escape from it are both references to Star Wars. The way the old people are treated, and later further explained by the Professor is in reference to the virtual world in The Matrix.
In this episode it is revealed that Professor Farnsworth is 160 years old.
This is the first time the Professor actually admits to "good news" being bad news. "Good news everyone! The University is bringing me up on disciplinary charges! Wait. That's not good news at all!" This is also the first time he says "Bad news everyone!"
The unfinished time machine shown in this episode is later finished in "The Late Philip J. Fry"